AutoLISP was derived from a very early version of XLISP, which was created by David Betz. The language was introduced in AutoCAD Version 2.18 in January 1986,

and continued to be enhanced in successive releases up to Release 13 in February 1995. After that, its development was neglected by Autodesk in favor of more fashionable development environments like VBA, .NET and ObjectARX. However, it has remained AutoCAD’s primary user customization language.

Visual-LISP, a considerably enhanced version of AutoLISP including an IDE, debugger, and compiler, was developed and sold by third party developer Basis Software. Vital LISP was a superset of the existing AutoLISP language that added VBA-like access to the AutoCAD object model, reactors (event handling for AutoCAD objects), general ActiveX support, and some other general Lisp functions. Autodesk purchased this, renamed it Visual LISP, and briefly sold it as an add-on to AutoCAD 14 released in May 1997. It was incorporated into AutoCAD 2000 released in March 1999, as a replacement for AutoLISP. Since then Autodesk has chosen to halt major enhancements to Visual LISP in favor of focusing more effort on VBA, .NET and ObjectARX.

AutoLISP has such a strong following that other CAD application vendors added it to their own products. FelixCAD, Bricscad, IntelliCAD and others have AutoLISP functionality, so that AutoLISP users can consider using them as an alternative to AutoCAD. Most development involving AutoLISP since AutoCAD 2000 is actually performed within Visual LISP since the original AutoLISP engine was replaced with the Visual LISP engine. There are thousands of utilities and applications that have been developed using AutoLISP or Visual LISP (distributed as LSP, FAS and VLX files).